Opioid use disorder (OUD) is a chronic condition driven by neuroadaptations that promote continued drug use. Identifying molecular mechanisms supporting these adaptations remains a major challenge. An understudied area…
Blood-based biomarkers could broaden access to Alzheimerâs disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau…
Increased reliance on anaerobic glycolysis is a hallmark of cancer metabolism that is traditionally used by FDG-PET for lesions and metastases detection. Glucose-based chemical exchange saturation transfer (glucoCEST)…
C-reactive protein (CRP) in cerebrospinal fluid (CSF) has been proposed as a highly specific diagnostic marker for bacterial meningitis. We investigated whether systemic inflammation, in the absence of CNS infection, can…
Inferring hidden environmental structures, which commonly involves learning arbitrary probability distributions from limited samples, is essential to optimal and adaptive behaviors across various cognitive domains…
Cognitive-behavioral therapy (CBT) is the first-line treatment for obsessive-compulsive disorder (OCD), yet a significant number of patients do not achieve remission or substantial symptom relief. This study aims to…
Nomophobia, defined as the fear of being without access to a smartphone, is increasingly prevalent among students and has been associated with increased anxiety, and reduced psychological well-being. Although most…
Dog-training experts often evaluate dogâhuman interactions accurately, but the neural basis of this expertise is not well understood. Previous studies have shown that higher activation in the posterior superior…
A new study shows how exercise releases muscle-derived "exerkines" that protect dopamine neurons and counter sarcopenia in Parkinson's disease.
A new study introduces "apical hypercontextualisation," explaining how psychedelics target serotonin receptors on layer V pyramidal neurons to shift brain processing from raw sensory input toward associative context.
Researchers uses The Virtual Brain to show how regional acetylcholine receptor density shapes whole-brain activity and localized sleep waves.
Early-life stress elevates the enzyme SETD7 in dopamine neurons, uncoiling DNA and creating a physical scar that heightens adult stress vulnerability.
A new study demonstrates that human overconfidence persists because its decision-making costs make it a credible, peacock-like evolutionary signal of underlying ability.
An intensive seven-day meditation retreat triggered striking changes across the brain and body, including shifts tied to neuroplasticity, immunity, metabolism, and natural pain relief. Participants ...
In a 2024 study, roughly 1 in 100 taxi and ambulance drivers died of Alzheimer’s, compared with 1 in 60 people overall. The probable reason? The continuous real-time mental navigation the drivers ...
Brain aging study: Brain immune cells begin changing around midlife, a new study reveals. Microglia in the hippocampus gradually decline after age fifty, researchers found. These cells appear replaced ...
Discover how honeybees can rejuvenate aging brains, raising possibilities for human cognitive health and new approaches to combat age-related decline.
Researchers have developed a computer model of the human cortex that links its microscopic chemistry to its brain-wide patterns of activity, providing new evidence that regional differences in receptor density help shape…
From smoking to stress, scientists identify everyday habits that could be quietly rewiring your brain toward dementia.
Seeing feels immediate; we open our eyes and the world seems to appear as a continuous stream. But some visual illusions show that events occurring later can change how we perceive what happened earlier, suggesting that…
Blocking the glycine transporter SLC6A20 restored important brain signaling and improved social, communication, and repetitive behaviors in autism-related mouse models. The treatment also worked in human brain organoids…
An international study led by Mayo Clinic researchers has identified interleukin-6 (IL-6) receptor blockers as a promising option for preventing relapses in myelin oligodendrocyte glycoprotein antibody-associated disease…
The pace at which a person walks down a hallway looks like the most ordinary thing in the world, yet a growing body of research treats it as a window into the brain. Scientists studying aging have ...
New research from NYU Langone Health found that people who avoid three vascular risk factors in middle age had about 13 more dementia-free years.
The risk of cognitive decline increases as we get older, with about 42% of Americans over the age of 55 expected to develop dementia during their lives. The research, published Wednesday in the ...
Although dementia traditionally affects older people there are still several ways in which we can help to prevent or delay it while we're still young. Doctors have previously looked into dementia to ...
Many people worry about developing dementia as they get older and wonder if there's anything they can do to stop it. The honest answer is that there is currently no proven way to prevent dementia, ...
There are still opportunities in midlife to prevent dementia or delay its onset, a new study finds.
Many people worry about developing dementia as they get older and wonder if there's anything they can do to stop it. The honest answer is that there is currently no proven way to prevent dementia, ...
However, a new study shows a simple change in how you walk may reduce your dementia risk by 50% —and it has nothing to do with walking 10,000 steps per day or for 15 minutes after every meal. Spoiler ...