Rapid-acting antidepressants like ketamine and serotonergic psychedelics show promise for treatment-resistant depression (TRD), but the molecular mechanisms that contribute to their therapeutic effects remain unclear…
The primate brain exhibits complex RNA alternative splicing heterogeneity crucial for functional complexity, yet systematic spatial isoform characterization has been lacking. We developed Fullscope-seq, a full-length…
The development of dual agonists for the glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) has been a landmark moment in the treatment of type 2 diabetes and…
The evaluation of automotive sound quality is of considerable significance for improving driving comfort. However, existing methodologies suffer from notable limitations, including inconsistencies in subjective…
Persistent neuroinflammation is a hallmark of central nervous system (CNS) injury, driving neuronal loss and functional deficits. While microglial lipid metabolic reprogramming, particularly lipid droplet accumulation…
To explore the autonomic nervous function characteristics of generalized anxiety disorder (GAD) patients with different sleep duration subtypes and clarify the association between sleep phenotypes and autonomic nervous…
In multiple sclerosis (MS), the retina can be affected by acute inflammation during optic neuritis and by chronic neurodegeneration involving retinal cells. Teriflunomide is an approved immunomodulatory therapy that…
β-Damascone is a naturally occurring aroma compound with pronounced fruity-floral and âsweet-smellingâ notes. Although well characterized olfactorily, its gustatory role and sweetness-enhancing property remain…
Deep brain stimulation (DBS) constitutes one of the few therapeutic strategies for advanced Parkinsonâs disease. Although DBS causes rapid alterations in neuronal metabolism, whether it remodels the circulating…
Leukocyte Immunoglobulin-Like Receptor A3 (LILRA3) gene variants have been previously associated with multiple sclerosis (MS). This study aimed to explore the prevalence of LILRA3 gene variants in a Greek cohort of…
Levodopa combined with a peripheral DOPA decarboxylase inhibitor (DDCI) is the first-line treatment for Parkinson’s disease (PD), yet interindividual response variability remains poorly understood. Whether DDCIs…
Rare genetic variants in the glycine receptor (GlyR) α2 subunit gene (GLRA2) are associated with autism spectrum disorder, developmental delay, and intellectual disability, often accompanied by microcephaly, language…
Olfactory groove meningiomas (OGMs) are slow-growing tumors that compress the orbitofrontal cortex, potentially causing executive dysfunction, affective disturbances and behavioral alterations. However, prospective…
Post-stroke depression (PSD) is a common complication among stroke survivors and is closely associated with executive function deficits, yet effective treatments targeting both domains remain limited. Transcutaneous…
As the population continues to age, a rise in the number of individuals experiencing mild cognitive impairment or dementia symptoms is anticipated. Brain atrophy is strongly associated with cognitive decline that could…
Glioblastoma multiforme (GBM) remains a highly lethal brain malignancy, and although maximal surgical resection can improve outcomes, many tumors are not amenable to aggressive surgery due to proximity to critical…
Understanding how the brain evaluates aversion and appetition to guide behavior is an important question. Here, we investigated the role of dopamine signaling in the tail of the striatum (TS) in regulating competing…
Behavioral state fluctuations profoundly impact episodic memory processing. To explore the underlying mechanisms, we recorded CA1 place cells in head-fixed male mice and focused on awake immobility to capture spontaneous…
Neurodegenerative disorders, such as Alzheimerâs, dementia, and Parkinsonâs disease, pose a significant worldwide health concern owing to their progressive and irreversible nature. Early and precise prediction of…
Stereotypical motor movements (SMM) are a core diagnostic feature of autism and remain difficult to quantify across individuals and developmental stages in an efficient and valid way. The current paper presents a novel…
Influenced by Regulatory Focus Theory, message framing is crucial in persuasive communication, particularly in marketing. This effect is further enhanced when integrated with artificial intelligence-generated content…
In the version of the article initially published, Corey C. Harwell was inadvertently omitted from the author list. Corey C. Harwellâs laboratory, in collaboration with Christopher M. Reid, generated the unpublished…
An important but under-explored use case for socially assistive robotics is in community formation. In this work, we conduct a novel investigation into the ability of a social robot to encourage human-human relationships…
Sensory difficulties in attention deficit hyperactivity disorder (ADHD) exacerbate behavioural and emotional challenges. Despite their clinical prevalence, objective psychophysical assessments of sensory performance in…
In May 2026, OpenAI released a new math result that sent shock waves throughout the world of mathematical research. A major unsolved problem called the "unit distance conjecture" had just been resolved by generative AI.
Researchers at University College London suspect money troubles may place chronic stress on the systems involved in cognitive processing ...
Anyone who has spent time on a college campus lately has probably heard laments from faculty about their students' reading habits, or rather, nonreading habits. Such complaints are more than unfounded nostalgia for a…
Sustainable business practices are often seen as a luxury that only rich countries can afford. And these days, some of the biggest economies, including the U.S., are backtracking on those commitments.
Three studies presented at the Society of NeuroInterventional Surgery's (SNIS) 23rd Annual Meeting found that racial, geographic and socioeconomic disparities continue to influence stroke treatment and outcomes across…
A new study uses the HiToP framework to map motor symptoms to mental health dimensions in nearly 3,500 individuals.