Intraventricular hemorrhage (IVH), the most common, severe neurological complication of preterm birth, causes post-hemorrhagic hydrocephalus (PHH) in up to 30% of cases, which is associated with substantial morbidity…
Sleep deprivation substantially impairs driving performance, underscoring the need for Electroencephalography (EEG)-derived markers associated with driving-performance vulnerability under varying levels of sleepiness. In…
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists…
As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my motherâs APOE genotype with her showed me how…
In Alzheimer’s disease (AD), the role of Actin-binding LIM protein 1 (ABLIM1), which is highly enriched in the brain endothelium, in blood-brain barrier (BBB) dysfunction remains unclear. Our integrative multi-omics…
Peroxiredoxin 3 (PRDX3) encodes a mitochondrially localized antioxidant enzyme. Biallelic pathogenic variants in PRDX3 cause autosomal recessive spinocerebellar ataxia type 32 (SCAR32), a rare form of spinocerebellar…
γ-aminobutyric acid Type-A (GABAA) αβδ receptors regulate neuronal excitability and contribute to sleep, mood and motor coordination. However, the molecular arrangements of these receptors and the basis of GABA…
Sodium fluoride (NaF) is a ubiquitous environmental pollutant that is widespread and has detrimental impacts on ecosystems and health. Developmentally, fluoride exposure enhances oxidative stress, including neurotoxicity…
Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to…
Both the immune system and gut microbiome play important roles in the physiological response to stress, yet their interplay under conditions of long-term continuous stress remains poorly understood due to the lack of…
Tamoxifen is widely used clinically as an anticancer therapy and is also commonly employed in transgenic mouse models to induce Cre-dependent recombination. Although its toxicity has been documented across multiple cell…
Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence…
The human capacity to construct and share subjective experiences from diverse sensory inputs is central to human cognition, and is vividly exemplified through music listening. Direct, focused music perception has been…
College students often struggle to regulate emotions under changing academic and social stress, highlighting the need for interventions targeting adaptive emotion regulation (ER). Here, we tested a 5-week online…
Despite the high prevalence of accommodative and non-strabismic binocular dysfunctions, commonly used approaches to investigating the impact of routine screen use on visual health often do not account for individual…
Brain fog, which is characterised by cognitive impairment and emotional disturbance, is frequently reported by individuals with celiac disease (CD). However, there was no Turkish-language instrument available to assess…
For patients facing a diagnosis of glioblastoma—one of the most aggressive and devastating forms of brain cancer—the standard path forward has long meant invasive open-skull surgery and a daunting prognosis.
One of the major challenges in glioma surgery is that tumor boundaries are often difficult to define. Diffuse gliomas can infiltrate surrounding brain tissue beyond what surgeons can see directly or what conventional…
Northwestern Medicine scientists have uncovered a previously hidden immune environment in the thymus that may help drive myasthenia gravis (MG), a chronic autoimmune disease that causes muscle weakness and fatigue…
Researchers from Houston Methodist and the University of Cambridge have developed a flexible device that wraps around the spinal cord and can simultaneously interpret multiple signals related to movement, sensation and…
Many people find themselves losing appetite—or, conversely, overeating—in difficult situations, and these common reactions to stress suggest that the mind and metabolism are deeply connected. A new study from the…
New treatments for Huntington's disease could be on the horizon following research led by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab).
As we move through everyday life, our brains engage in a huge variety of cognitive tasks. For example, during a grocery run, we might have to recall the items for a recipe, remember where the clerk said the flour was…
Beginning in the late 1990s, air pollution declined in New York City following the implementation of clean air and climate policies. According to new research by scientists at Columbia University Mailman School of Public…
Alzheimer's disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2…
Researchers from the UT and Radboudumc have steered a tiny screw-shaped robot through real brain tissue, controlled only by a magnet outside the body. The test used sheep brain tissue in the lab. The team built a model…
Exposure to common forms of outdoor air pollution may be linked to structural changes in brain regions that are especially vulnerable to Alzheimer's disease, according to a new study led by researchers from the USC Mark…
Picture a driver approaching a sharp bend on a country road. As the car turns, they move their foot to slow down. But instead of pressing the brake, they hit the accelerator. The car surges forward.
Recently, the Australian Football League (AFL) was rocked when it was revealed a Geelong player with a history of concussion had been asked to waive his legal rights to claim for any future brain trauma.
An eight-year Finnish study found that children who spent more time on screens tended to show better cognitive processing as teenagers, challenging common assumptions about screen use. Researchers say the key may be…