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IntroductionSense of belonging is widely regarded as an important contributor to student success, yet its associations with academic outcomes in postsecondary education remain unclear.MethodsThis meta-analysis…
BackgroundThe motivational orientation of adolescent athletes is a primary determinant of their long-term trajectories, yet the precise mechanisms through which the relational foundation provided by parents is…
IntroductionPlatform work is increasingly organized through algorithmic rules and standardized performance systems that may leave workers feeling treated as replaceable instruments rather than as full persons. Drawing on…
This article introduces the Somatic Codification Hypothesis (SCH), a theoretical framework that models the karaṇa system of the Nāṭyaśāstra—the foundational Sanskrit treatise on performance—as a systematic codification…
BackgroundWith the increasing prevalence of online social interaction, university students often experience insufficient satisfaction of their relatedness needs. Online authentic self-presentation has become a common…
ObjectiveThis study aimed to explore the relationship between perceived environmental support for value education (PESVE) and mental health among civil aviation flight university students, and to examine the mediating…
ObjectiveTo examine whether fact-checking COVID-19 fake news on social media corrects false beliefs among Chinese youths, and identifies factors influencing its effectiveness.MethodsWe conducted an experiment with 660…
Nightmares are a hallmark of post-traumatic stress disorder (PTSD), yet pharmacological treatments remain limited. Here we conducted a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the…
The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are thought to participate in pattern separation, pattern completion and memory encoding, yet no large-scale neuronal wiring diagram exists for these…
Dopamine and noradrenaline have conserved roles in control of physiology and behaviors of vertebrates. However, vertebrate genetic models completely devoid of catecholamines are not available. We generated genetically…
Post-operative delirium (POD) is a serious complication of surgery particularly in older adults, characterized by acute disturbances in consciousness and cognition and associated with increased mortality and long-term…
The present study investigated the therapeutic potential of quercetin nanoparticles (QNPs), administered alone or in combination with levodopa/carbidopa (L/C), against reserpine-induced neurochemical alterations and…
Variants in GBA1, encoding lysosomal glucocerebrosidase (GCase), are risk factors for Parkinsonâs disease (PD), which is characterized by α-synuclein (αSyn) accumulation and lysosomal dysfunction. Nonetheless, the…
Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally…
Alzheimer’s disease (AD) is a chronic, multifactorial neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Pathological hallmarks include extracellular amyloid-β (Aβ) deposition and…
Upper limb impairment is one of the most common motor consequences after stroke, and valid assessment tools are essential for evaluating motor capacity. The Wolf Motor Function Test (WMFT) is widely used to measure upper…
Standing up from sitting is a common yet mechanically demanding activity of daily living. Those with motor impairments often have difficulties performing sit-to-stand transfers independently. Robotic devices can help…
Women experience addiction differently than men, with the nature and magnitude of these differences dependent on the clinical phenotype (e.g., progression to addiction vs. relapse vulnerability) and context (e.g., phase…
HIV-Tat and morphine synergistically exacerbate neuroinflammation and DNA damage, yet the mechanisms linking the DNA damage response (DDR), chromatin remodeling, and innate immune activation remain poorly understood…
Astrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinsonâs disease (PD)-associated mutation LRRK2-G2019S…
Cerebrospinal fluid (CSF) is thought to facilitate brain waste clearance and immune surveillance, yet its compartmentalization remains unclear. Previous work, using invasive dynamic intrathecal MRI contrast imaging…
Neural manifolds refer to the low-dimensional shapes formed by populations of spiking neurons. This intrinsic population geometry can be physically emulated by electronic devices, facilitating near-training-free…
The astringency surface sub-quality is pivotal to red wine perception, yet its neural bases remain unclear. The approaches of non-invasive neurophysiological techniques, sensory analysis, liquid chromatography-mass…
To examine whether serial casting promotes autonomic nervous system adaptation in children with spastic CP, in comparison to ankle-foot orthoses (AFOs) and no intervention. Thirty children with spastic CP (aged 6–12…
Neuronal polarization is essential for functional compartmentalization, enabling dendritic synaptic integration and axonal action potential generation. Although structural differences in mitochondria across compartments…
Reshaping cortical circuits through stimulation represents an emerging therapy for the restoration of cognitive function1â5, yet the biological mechanisms that underlie its effects remain largely unexplored in humans…
G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual…
Spontaneous biological oscillations are typically attributed to specific architectures within metabolic or gene regulatory networks. Here, we uncover a more general mechanism arising from the interplay between cellular…
Psychological stress is a major precipitating factor for neuropsychiatric disorders, and the gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host…
Understanding how adverse life events trigger stress-related behavioural changes remains an unresolved challenge. The amygdala is integral to emotion and stress responses1 and comprises astrocytes, neurons and other…
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