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BackgroundChildhood suicide attempts requiring pediatric intensive care unit (PICU) admission represent some of the most severe forms of self-harm and are associated with substantial morbidity and mortality. This study…
IntroductionImmersive and wearable virtual reality (VR) is an emerging technology with growing potential to support assessment and intervention ifor autistic people. The methodological heterogeneity of existing studies…
IntroductionDysregulation of the autonomic nervous system has been implicated in nonsuicidal self-injury (NSSI) in laboratory studies of physiological reactivity, but it remains unclear whether self-reported everyday…
BackgroundPsoriasis is a long-lasting, immune-related inflammatory skin disorder that has been increasingly recognized to be a systemic disorder with significant neuropsychiatric symptoms.ObjectiveTo critically evaluate…
BackgroundAppearance anxiety has increasingly been recognized as an important public mental health concern, characterized by persistent concerns regarding physical appearance and heightened sensitivity to social…
ObjectiveMood disorder classification from neuroimaging alone remains limited by single-modality constraints and population-level heterogeneity. This study proposes a fusion-based machine learning framework combining…
BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, often—but not always—characterized by inattention, hyperactivity/impulsivity, and deficits in executive functions…
Accumulating evidence implicates sleep and circadian rhythm disruption in substance use disorders, including opioid use disorder (OUD). To understand whether weaker light exposure time cues are observed in patients with…
Individuals with psychiatric disorders frequently experience comorbid cardiometabolic conditions, complicating treatment and worsening health outcomes. Both psychiatric and cardiometabolic disorders have been…
Migraine and tension-type headache (TTH) are highly prevalent primary headache disorders. Neck pain is common among patients with migraine or TTH, but objective biomarkers for the neck’s myofascial involvement within the…
Integrating different sources of information is essential to successful spatial navigation. For instance, animals often rely on a combination of visual impressions, self-motion, olfaction, and other signals to navigate…
Neuronal senescence, triggered by oxidative stress and inflammatory responses, is a significant risk factor for brain aging, ultimately leading to cognitive decline. Apelin-13, an exercise-induced myokine, exhibits…
Accumulating evidence indicates that gut microbiota plays a role in the progression of Parkinson’s disease (PD). Microbiota-based treatments for prodromal PD, which is accompanied by a wide range of neuropsychiatric…
Traumatic brain injury (TBI) elicits robust neuroinflammation and oxidative stress, coupled with an acute inhibition of macro-autophagy (autophagy) in neurons and microglia. Rubicon (Rubcn), a Beclin1 interacting protein…
The platelet to highdensity lipoprotein cholesterol ratio (PHR) is an emerging indicator reflecting the balance between thrombogenesis and lipid metabolism inflammation. This study aimed to investigate the relationship…
Hereditary defects in the function of the inwardly rectifying potassium channel Kir7.1 in the retinal pigment epithelium are associated with the ocular diseases retinitis pigmentosa, Leber congenital amaurosis, and…
The workings of the brain are often compared to those of a computer. Some researchers are testing this analogy to its limits, attempting to build computers containing laboratory-grown cultures of brain cells. In doing…
End-stage renal disease (ESRD) patients exhibit a high prevalence of multidimensional frailty, yet its neurobiological correlates remain unclear. This study investigated neuroimaging correlates of frailty in ESRD and…
Sleep deprivation can be dangerous, but it’s difficult to measure.Credit: Getty How does the brain know when it’s time to wake up? Researchers have identified1 a chemical signal that serves as a timer in the mouse brain…
Two scientists blend their love of music and science in different ways. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our…
This study investigates how heterogeneity in lifestyle and physical fitness shapes patterns of brain ageing in depression. The study sample included medically healthy adults from the UK Biobank (44–82 years) with a…
Habits are essential for sustaining adaptive behaviors but can also lead to maladaptive behaviors such as compulsive and addictive disorders. They emerge through a shift in decision-making from motivation-driven strategy…
Calcium imaging is a central method in neuroscience but it records neuronal activity only indirectly and thereby produces results that are difficult to interpret. Here we evaluate the GCaMP8 calcium indicator variants…
The brainâs capacity for information processing depends on precisely regulated energy dynamics. Yet how metabolic supply adapts to shifting computational demands across brain states remains unclear. Using wide-field…
Spontaneous subarachnoid hemorrhage (SAH) remains a life-threatening type of hemorrhagic stroke. Astrocytes are key cellular responders after SAH. We designed the current study to elucidate the global astrocyte reaction…
Post-mortem tau pathology is frequently observed in Parkinsonâs disease (PD) using immunohistochemistry (IHC) to measure large inclusions. However, small protein aggregates that precede inclusions are considered a…
Correction to: Molecular Psychiatry https://doi.org/10.1038/s41380-026-03560-0; published online 02 April 2026 Following publication of this article, the authors identified an error in the corresponding authorship…
Voltage-gated sodium channels regulate neuronal excitability and synaptic transmission in the postnatal and adult brain. The gene SCN2A, encoding the sodium channel Nav1.2, regulates synaptic development and variants in…
Brain health is central to Africaâs development, but current financing and policy frameworks remain poorly matched to the scale and distribution of need. Upstream economic risks, such as poverty, inequality, food…
In order to improve their performance, musicians devote thousands of hours to practising their instrument. However, how practise shapes the behaviour of muscles involved in music-making is not yet fully understood. Using…
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