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ObjectiveUnderstanding low-carbon behavior remains a significant challenge due to the complexity of environmental decision-making and the persistent intention–behavior gap. While the Theory of Planned Behavior (TPB) and…
To explore the chain mediating effect of perspective taking and general trust between social value orientation and college students’ aggressive behavior, and to provide scientific evidence for promoting college students’…
IntroductionMothers and caregivers of children with intellectual and developmental disabilities often experience depression, anxiety, parenting stress, emotional exhaustion, and reduced psychological wellbeing because of…
Lipocalin-2 (LCN2) has been implicated in the pathogenesis of sepsis-associated encephalopathy (SAE). Our previous work demonstrated a significant increase in astrocyte-derived LCN2 in the hippocampal region during SAE…
Nucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a critical…
Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we…
Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock…
With growing knowledge of the neural circuitry involved in alcohol use disorder (AUD), interest in developing neural-circuit-based therapeutic tools, including transcranial magnetic stimulation (TMS), for people with AUD…
Before hearing onset, inner hair cells in altricial mammals show spontaneous electrical activity crucial for proper auditory pathway development. This activity is finely regulated by descending efferent nerves from the…
To establish a rat model of cerebral ischemiaâreperfusion injury (CIRI) to investigate how chloride intracellular channel protein 1 (CLIC1) exacerbates neuronal damage and to assess the neuroprotective effect of its…
Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy)…
Neuroinflammation is responsible for many neurodegenerative diseases and conditions. In this study, neuroprotective effect of resveratrol was aimed to be investigated in lipopolysaccharide (LPS)-induced neuroinflammatory…
Intraventricular hemorrhage (IVH), the most common, severe neurological complication of preterm birth, causes post-hemorrhagic hydrocephalus (PHH) in up to 30% of cases, which is associated with substantial morbidity…
Sleep deprivation substantially impairs driving performance, underscoring the need for Electroencephalography (EEG)-derived markers associated with driving-performance vulnerability under varying levels of sleepiness. In…
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists…
As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my motherâs APOE genotype with her showed me how…
In Alzheimer’s disease (AD), the role of Actin-binding LIM protein 1 (ABLIM1), which is highly enriched in the brain endothelium, in blood-brain barrier (BBB) dysfunction remains unclear. Our integrative multi-omics…
Peroxiredoxin 3 (PRDX3) encodes a mitochondrially localized antioxidant enzyme. Biallelic pathogenic variants in PRDX3 cause autosomal recessive spinocerebellar ataxia type 32 (SCAR32), a rare form of spinocerebellar…
γ-aminobutyric acid Type-A (GABAA) αβδ receptors regulate neuronal excitability and contribute to sleep, mood and motor coordination. However, the molecular arrangements of these receptors and the basis of GABA…
Sodium fluoride (NaF) is a ubiquitous environmental pollutant that is widespread and has detrimental impacts on ecosystems and health. Developmentally, fluoride exposure enhances oxidative stress, including neurotoxicity…
Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to…
Both the immune system and gut microbiome play important roles in the physiological response to stress, yet their interplay under conditions of long-term continuous stress remains poorly understood due to the lack of…
Tamoxifen is widely used clinically as an anticancer therapy and is also commonly employed in transgenic mouse models to induce Cre-dependent recombination. Although its toxicity has been documented across multiple cell…
Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence…
The human capacity to construct and share subjective experiences from diverse sensory inputs is central to human cognition, and is vividly exemplified through music listening. Direct, focused music perception has been…
Healthy brain dynamics evolve in the direction far from thermodynamic equilibrium. The temporal asymmetry nature recently has been described in several normal and pathological brain states. However, whether the temporal…
College students often struggle to regulate emotions under changing academic and social stress, highlighting the need for interventions targeting adaptive emotion regulation (ER). Here, we tested a 5-week online…
Most adults have limited understanding of child development, yet their perceptions of development influence their decisions about whether to support childrenâs autonomyâsuch as support for autonomy-limiting…
STEM (Science, Technology, Engineering, and Mathematics) online education is increasingly characterized by high cognitive demands and complex interactive environments, which makes task interruptions a critical factor…
Despite the high prevalence of accommodative and non-strabismic binocular dysfunctions, commonly used approaches to investigating the impact of routine screen use on visual health often do not account for individual…
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