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Friedreichâs ataxia (FA) is a mitochondrial disease caused by frataxin deficiency that leads to progressive neurodegeneration and cardiomyopathy. Effective disease-modifying therapies remain limited. Here we show that…
Activation of microglia is a prominent feature of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that leads to the death of motor neurons. A key component of this activation is elevated expression of…
NASA has a robust history of biomedical investigations using rodent models in spaceflight. The results from these experiments have provided significant insights into the effects of spaceflight on mammalian physiological…
Postpartum depression (PPD) is among the most common complications of childbirth, and identifying novel treatments is vital. We aimed to identify potential drug targets for PPD by integrating the plasma proteome…
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with variable long-term outcomes. Blood-based biomarkers for prognostic prediction remain underdeveloped. We aimed to develop a peripheral blood…
Electroconvulsive therapy (ECT) is effective for treating depression. Recent studies suggest that ECT can induce cortical spreading depression (CSD), which may have clinical benefits. However, the probability of CSD…
Early regulatory problems (RPs, i.e. problems with crying, sleeping and feeding), are associated with increased susceptibility to avoidant personality traits and peer relationship issues in adulthood. RPs have been…
We present and validate a pioneering ‘IHC/LCM-Seq’ method for transcriptome profiling of spatially defined neuronal cell types detected with immunohistochemistry in sections of formaldehyde-fixed human brains…
Microglia are central regulators of retinal immune homeostasis, yet their pathogenic states in retinal degeneration remain less well understood. Here we identified a distinct subset of lipid-accumulated reactive…
Drosophila olfactory sensory neurons tend to express a single ligand-specific receptor, following a one-receptor-per-neuron rule expected to apply broadly across insects. Recent work challenges this view by showing that…
Preterm birth disrupts early brain development, increasing the risk of cognitive difficulties. However, its long-term effects on functional brain network energy, a metric of large-scale network stability and…
Physical multimorbidity and loneliness are increasingly recognised as public health concerns, but the nature of their potential relationships remains unclear. Here we report bidirectional associations between physical…
Abundant evidence shows that when listening to speech or reading text, we continuously make high-level predictions about upcoming words â their content, meaning, and relationship to the overall narrative. Does this…
Visual food stimuli are widely used in food perception and evaluation research, but are often limited by a lack of control of confounding variables. AI-generated food images may be a viable but yet understudied…
This paper examines how long-term transformations in pottery styles from the Jutland Peninsula (Denmark) may relate to patterns of visual attention between 4600 and 1 BCE. Free-viewing eye-tracking experiments were…
Canada ranks among the worldâs most prominent immigrant-receiving countries, and immigration has become an integral part of its demographic, economic, and cultural landscape. This study investigates the factors…
Increasing multiculturalism and globalization have increased the discrepancies between socially-shared norms and personal values. This study examined whether the association between Cultural Estrangement (CE) and…
In recent years, “attention” has become increasingly important as a scientific and philosophical topic, as an object of empirical research, and more broadly, as a key concern in societal debates about the digital…
Generative artificial intelligence (AI) is increasingly used in higher education, but its associations with studentsâ broader psychological outcomes remain uncertain. This cross-sectional study examined generative AI…
The constant increase in the use of virtual worlds in recent decades has raised concerns about their potential effects on usersâ mental health. However, the great heterogeneity of the scientific literature on this…
Artificial Intelligence (AI) makes it feasible to generate highly finished ads for pretesting, before final, human production. In this ‘proof of concept’ study, AI was used to make static and multi-shot video ads. When…
The present article describes a Spanish lexical decision dataset designed to support analyses of how orthographic letter-position coding relates to affective properties during visual word recognition. The dataset…
Ever feel that the arrival of summer sun makes you feel a bit dopey? You wouldn't be the only one. Soaring temperatures are known for their ability to slow our thought processes, making even everyday tasks seem like a…
It was such a strange place for headphones that there was no way you'd forget. A few hours later, you want to go to the gym, and the headphones are gone. Not gone, exactly, because they're still next ...
Volunteers with YouthLine traveled to Washington, D.C., to advocate for peer-to-peer mental health services, highlighting demand for youth crisis support.
A new study finds most of the gap is driven by preventable physical disease. The post Serious mental illness may shorten life by up to 20 years, and suicide is not the main cause first appeared on ...
The Coalition’s future goals include increasing youth leadership activities and opportunities, as well as support and education for parents and trusted adults to prevent substance misuse and suicide - ...
A person's sleep patterns could be an early sign of Alzheimer's disease, a new study says. A greater number of micro-awakenings during sleep is linked to a greater genetic risk for Alzheimer's, researchers report in the…
As animals learn to self-administer cocaine, specific brain networks rapidly expand and then shrink. Using advanced imaging, researchers discovered that the cells controlling this addictive habit constantly swap in and…
Thomas's phone alarm buzzes at 9:30 p.m.—it's time for the aspiring bodybuilder to start injecting several banned peptides into his stomach.
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